CYP2C19: Drug Metabolism (Ultra-Rapid)

rs12248560 · Pharmacogenomics

CYP2C19 affects how you metabolize a wide range of medications including clopidogrel (Plavix), PPIs, antidepressants, and antifungals.

What This SNP Does

CYP2C19 is a major drug-metabolizing enzyme. The *17 allele (rs12248560 T) increases enzyme activity, making you an ultra-rapid metabolizer. This means certain drugs are cleared faster than expected — pro-drugs like clopidogrel work BETTER (more active metabolite), while other drugs may need higher doses. The FDA has issued pharmacogenomic guidance for several CYP2C19-affected drugs.

Genotype Meanings

Genotype	Status	What It Means
CC	Normal	Standard CYP2C19 activity. Normal drug metabolism.
CT	Rapid	Increased enzyme activity. Pro-drugs (clopidogrel) may work better. Some drugs cleared too fast.
TT	Ultra-rapid	Significantly increased activity. PPIs may be less effective. Clopidogrel activation enhanced.

What You Can Do

Ultra-rapid metabolizers may need dose adjustments for PPIs (proton pump inhibitors), certain antidepressants (citalopram, escitalopram), and antifungals (voriconazole). Share this information with your prescribing physician and pharmacist.

This information is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before making health decisions based on genetic data. Genome Decoder does not diagnose, treat, or prevent any disease.