๐Ÿงฌ SNP Database

Browse health-relevant genetic variants. Each page explains what the SNP does, what your genotype means, and what you can do about it.

rs1801133

MTHFR C677T โ€” Methylation & Folate

Affects folic acid conversion to methylfolate. Impacts DNA repair, detoxification, and neurotransmitter production. Health rs4680

COMT Val158Met โ€” Warrior vs Worrier

Determines dopamine clearance speed. Influences stress response, cognition, and pain sensitivity. HealthPharmacogenomics rs1800497

DRD2/ANKK1 Taq1A โ€” Dopamine Receptors

Affects dopamine receptor density. Influences reward sensitivity and addiction susceptibility. Health rs9939609

FTO โ€” Obesity Risk

The most significant common genetic contributor to obesity risk. Exercise reduces risk by up to 27%. Disease Risk rs429358

APOE ฮต4 โ€” Alzheimer's Risk (Part 1)

The strongest common genetic risk factor for Alzheimer's disease. Determines ฮต4 carrier status. Disease Risk rs7412

APOE ฮต2 โ€” Protective Variant (Part 2)

Identifies the protective APOE ฮต2 allele. Combined with rs429358 for full APOE typing. Disease Risk rs1801131

MTHFR A1298C โ€” Methylation (Secondary)

Second MTHFR variant. Compound heterozygosity with C677T significantly affects methylation. Health rs1800795

IL-6 โ€” Inflammatory Baseline

Affects baseline interleukin-6 levels. Influences chronic inflammation and recovery. Health rs7903146

TCF7L2 โ€” Type 2 Diabetes Risk

Strongest common genetic risk factor for type 2 diabetes. Affects insulin secretion. Disease Risk rs12255372

TCF7L2 โ€” Diabetes Risk (Secondary)

Second TCF7L2 variant independently associated with type 2 diabetes. Disease Risk rs1800566

NQO1 โ€” Detoxification

Key detoxification enzyme. Affects benzene toxicity risk and chemotherapy response. HealthPharmacogenomics rs4988235

MCM6/LCT โ€” Lactose Tolerance

Determines whether you produce lactase as an adult. 65% of humans are lactose non-persistent. Trait rs762551

CYP1A2 โ€” Caffeine Metabolism

Fast vs slow caffeine metabolizer. Affects how coffee impacts your sleep and heart health. Pharmacogenomics rs1799945

HFE H63D โ€” Iron Overload

Hemochromatosis risk. Treatable with early detection and regular blood donation. Disease Risk rs1800562

HFE C282Y โ€” Hemochromatosis (Primary)

The major hereditary hemochromatosis mutation. ~1 in 200 Northern Europeans are homozygous. Disease Risk rs4149056

SLCO1B1 โ€” Statin Metabolism

Determines statin side effect risk. The wrong statin for your genotype can cause severe muscle pain. Pharmacogenomics rs12248560

CYP2C19 โ€” Drug Metabolism

Affects metabolism of clopidogrel, PPIs, antidepressants, and antifungals. Pharmacogenomics rs3892097

CYP2D6 โ€” Drug Metabolism (25% of Rx)

Metabolizes 25% of all prescription drugs. Poor metabolizers get no pain relief from codeine. Pharmacogenomics rs1805007

MC1R โ€” Red Hair / Fair Skin

The "red hair gene." Also affects pain perception and anesthesia requirements (+20%). Trait rs12913832

HERC2/OCA2 โ€” Eye Color

The single strongest determinant of eye color. Explains up to 74% of variation in Europeans. Trait rs1426654

SLC24A5 โ€” Skin Pigmentation

One of the most significant genes for skin color variation. Near-fixed in Europeans (99.9% AA). Trait

These are just 21 of the 200+ SNPs we analyze in a full report.

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