HFE: H63D (Hemochromatosis)

rs1799945 · Iron Metabolism

HFE H63D is associated with hereditary hemochromatosis — iron overload that can damage the liver, heart, and pancreas if untreated.

What This SNP Does

HFE regulates iron absorption in the gut. The H63D variant (His63Asp) is a milder mutation than C282Y but still increases iron absorption. Compound heterozygosity (H63D + C282Y) carries significant risk. Hemochromatosis is one of the most treatable genetic conditions — regular blood donation or phlebotomy prevents all complications if caught early.

Genotype Meanings

Genotype	Status	What It Means
CC	Normal	No increased iron absorption from this variant.
CG	Carrier	Mildly increased iron absorption. Low risk alone; significant if also carrying C282Y.
GG	Homozygous	Moderately increased iron absorption. Monitor ferritin and transferrin saturation annually.

What You Can Do

All carriers should get serum ferritin and transferrin saturation tested. If elevated, regular blood donation is the simplest treatment. Avoid iron supplements and excessive vitamin C with iron-rich meals. The full report checks both HFE variants (H63D and C282Y) together.

This information is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before making health decisions based on genetic data. Genome Decoder does not diagnose, treat, or prevent any disease.