NQO1: Detoxification Enzyme

rs1800566 · Detoxification & Drug Metabolism

NQO1 rs1800566 affects a key detoxification enzyme involved in processing environmental toxins, drugs, and oxidative stress products.

What This SNP Does

NQO1 (NAD(P)H quinone dehydrogenase 1) is a phase II detoxification enzyme that protects against oxidative stress and activates certain chemotherapy drugs. The Pro187Ser variant reduces or eliminates enzyme activity. This has implications for benzene toxicity susceptibility, chemotherapy response, and overall detoxification capacity.

Genotype Meanings

Genotype	Status	What It Means
CC	Normal	Full NQO1 enzyme activity. Normal detoxification capacity.
CT	Reduced	~2-4x reduced enzyme activity. Decreased detoxification. Altered drug response.
TT	Absent	No functional NQO1 enzyme. Increased benzene toxicity risk. Altered chemotherapy metabolism.

What You Can Do

T allele carriers should minimize environmental toxin exposure (benzene, cigarette smoke). This variant is relevant for chemotherapy planning — inform your oncologist if you carry it. Antioxidant support (NAC, vitamin C, glutathione precursors) may compensate partially.

This information is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before making health decisions based on genetic data. Genome Decoder does not diagnose, treat, or prevent any disease.