IL-6: Inflammatory Baseline

rs1800795 · Inflammation & Immunity

IL-6 rs1800795 affects your baseline level of interleukin-6, a key inflammatory cytokine. This influences chronic inflammation risk, recovery from exercise, and susceptibility to inflammatory conditions.

What This SNP Does

IL-6 is a pro-inflammatory cytokine that plays dual roles: acute IL-6 from exercise is beneficial (anti-inflammatory), while chronic elevated IL-6 drives disease. The -174G>C promoter polymorphism affects transcription rate. The G allele is associated with higher IL-6 production and a more inflammatory baseline. This has implications for cardiovascular disease, type 2 diabetes, and recovery from injury.

Genotype Meanings

Genotype	Status	What It Means
GG	Higher IL-6	Higher baseline inflammation. Stronger acute immune response but elevated chronic inflammation risk.
GC	Intermediate	Moderate IL-6 production. Balanced inflammatory response.
CC	Lower IL-6	Lower baseline inflammation. May have reduced acute immune response but lower chronic disease risk.

What You Can Do

GG carriers benefit from anti-inflammatory strategies: omega-3 fatty acids (EPA/DHA), curcumin, regular moderate exercise, adequate sleep, and stress management. Monitor CRP levels as a proxy for chronic inflammation.

This information is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before making health decisions based on genetic data. Genome Decoder does not diagnose, treat, or prevent any disease.