CYP2D6: Drug Metabolism

rs3892097 · Pharmacogenomics

CYP2D6 metabolizes ~25% of all prescription drugs. Being a poor or ultra-rapid metabolizer can mean the difference between a drug working, doing nothing, or causing toxicity.

What This SNP Does

CYP2D6 is responsible for metabolizing approximately 25% of clinically used drugs, including codeine, tramadol, tamoxifen, many antidepressants (SSRIs, TCAs), beta-blockers, and antipsychotics. The rs3892097 variant (*4 allele) is the most common loss-of-function allele in European populations (~20-25% carrier frequency). Poor metabolizers cannot convert codeine to morphine (no pain relief) and may have toxicity from drugs that accumulate.

Genotype Meanings

Genotype	Status	What It Means
GG	Normal	Standard CYP2D6 activity. Normal drug metabolism for affected medications.
GA	Intermediate	Reduced CYP2D6 activity. May need dose adjustments for affected drugs.
AA	Poor metabolizer	Very low or absent CYP2D6. Codeine will NOT work for pain. Increased risk of side effects from SSRIs, beta-blockers. Alternative drugs recommended.

What You Can Do

Carry a pharmacogenomic card or note in your medical record. Poor metabolizers should avoid codeine (it won't work) and may need alternatives for tamoxifen, many SSRIs, and beta-blockers. This single variant can save you from years of ineffective medication.

This information is for educational purposes only and is not medical advice. Always consult a qualified healthcare provider before making health decisions based on genetic data. Genome Decoder does not diagnose, treat, or prevent any disease.